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(Seneca) is developing a pipeline of novel cancer agents using the nonpathogenic Seneca Valley Virus isolate 001 (SVV-001). Our first product, SVV-001 is being administered intratumorally in an Investigator Initiated Trial titled, “A Phase 1 Trial of the Oncolytic Virus SVV-001 in Combination with Nivolumab and Ipilimumab in Patients with Poorly Differentiated Neuroendocrine Carcinomas or Well-Differentiated High-Grade (Grade 3) Neuroendocrine Tumors”. SVV-001 is a targeted immunotherapy that selectively kills cancer cells expressing the SVV-001 receptor, TEM8. SVV-001 converts the tumor microenvironment from T-Cell resistant (“cold”) to T-Cell permissive (“Hot”). 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your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/1684264793072-QP5DC5B8APW5QN1FVZZ7/0001.jpg Novel Cancer Gene Delivery Platform - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.senecatherapeutics.com/home-1 daily 0.75 2023-05-16 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1391287286405-92Z4A4R3T2ZSZAKNVS9V/image-asset.jpeg Home - Transient (Copy) https://www.senecatherapeutics.com/home daily 1.0 2025-09-05 https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/e25a9237-17d2-4646-ad1e-039c75ba2ef1/WORLD+VACCINE+CONGRESS+PRESENTATION.jpg Home - THE WORLD VACCINE CONGRESS PRESENTATION Seneca's primary asset, SVV-001, is an oncolytic virus that selectively replicates in tumor cells expressing the TEM8 receptor, while being non-pathogenic in both humans and animals. Extensively evaluated in over 30 preclinical cancer models and three clinical trials for solid cancers including neuroendocrine and pediatric tumors. Combining SVV-001 with immune modulators, cytokines, and checkpoint inhibitors has shown synergistic anti-tumor effects in various animal studies. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/57d117af-f7b5-4962-99ba-7fae330375d5/THE+KOL+WEBINAR.jpg Home - KOL WEBINAR ON SENECA VALLEY VIRUS & TEM 8 In this KOL Webinar, SVV is being analyzed as an ideal cancer therapeutic by explaining advances from an structural biology perspective (Mihnea Bostina), clinical perspective (Aman Chauhan) and industry perspective (Paul Hallenbeck). https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1391287286405-92Z4A4R3T2ZSZAKNVS9V/image-asset.jpeg Home - Transient https://www.senecatherapeutics.com/academiccollaborator daily 0.75 2023-09-10 https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/55348c24-a3ef-455d-bc6d-18e7d7cbd41d/13.png Our Academic Collaborators https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/d0c26f52-d5eb-4e4f-99f5-8a7050772c15/Untitled+design-3.png Our Academic Collaborators - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/b43333d3-34d8-42b1-a507-8a4a409a1261/14.png Our Academic Collaborators https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/060cb31f-737f-4fc3-be92-300a37d819c8/15.png Our Academic Collaborators https://www.senecatherapeutics.com/pipeline daily 0.75 2025-12-10 https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/67bfc8d0-c554-49cd-bd4f-5b4bf8cbce43/pipeline+2.png Pipeline - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/1684264771615-CBFJU30IGQ8KVOCF45KG/Seneca+Therapeutics+Series+B+Deck+Spring+2022+v5.6_Page_23.jpg Pipeline Jayawardena et al. 2018. Proc Natl Acad Sci U S A. 2018 Nov 13; 115(46): E10934–E10940. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/9520d11b-7d1e-42fb-8deb-76862350e1d0/Picture+armed+virus+pipeline.jpg Pipeline https://www.senecatherapeutics.com/platform daily 0.75 2025-12-10 https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/1684264762453-QZZALC8FDTJTAN7KX56I/raghav-bhasin-Yl6VGTjWVkw-unsplash.jpg Platform https://www.senecatherapeutics.com/home-copy daily 0.75 2023-08-25 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1391287286405-92Z4A4R3T2ZSZAKNVS9V/image-asset.jpeg Home (Copy) - Transient (Copy) https://www.senecatherapeutics.com/home-copy-1 daily 0.75 2023-09-13 https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/f09db202-7aee-479f-92c6-4c0e00fa7923/banner.jpg Home (Copy) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/e25a9237-17d2-4646-ad1e-039c75ba2ef1/WORLD+VACCINE+CONGRESS+PRESENTATION.jpg Home (Copy) - THE WORLD VACCINE CONGRESS PRESENTATION Seneca's primary asset, SVV-001, is an oncolytic virus that selectively replicates in tumor cells expressing the TEM8 receptor, while being non-pathogenic in both humans and animals. Extensively evaluated in over 30 preclinical cancer models and three clinical trials for solid cancers including neuroendocrine and pediatric tumors. Combining SVV-001 with immune modulators, cytokines, and checkpoint inhibitors has shown synergistic anti-tumor effects in various animal studies. https://images.squarespace-cdn.com/content/v1/6463d71ae43ec27b6a2f2aa7/57d117af-f7b5-4962-99ba-7fae330375d5/THE+KOL+WEBINAR.jpg Home (Copy) - KOL WEBINAR ON SENECA VALLEY VIRUS & TEM 8 In this KOL Webinar, SVV is being analyzed as an ideal cancer therapeutic by explaining advances from an structural biology perspective (Mihnea Bostina), clinical perspective (Aman Chauhan) and industry perspective (Paul Hallenbeck). https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1391287286405-92Z4A4R3T2ZSZAKNVS9V/image-asset.jpeg Home (Copy) - Transient (Copy) https://www.senecatherapeutics.com/supportingdocs daily 0.75 2024-08-27 https://www.senecatherapeutics.com/miami-clinical-trial daily 0.75 2025-05-30